Definition of Single and Double Cannulas for Microinjection

       The microinjection cannula is a type of combined cranial administration device, which consists of a base, an inner injection tube, and a catheter cap. The head of the inner injection tube has been upgraded and optimized to enable more convenient, stable, and leak-proof connection with PE tubes. The inner injection tube is inserted into the base tube and fixed with a locking nut; after the administration is completed, the catheter cap is replaced and inserted into the inner tube of the base, aiming to prevent the growth of new tissue into the base tube. The base of the combined cranial administration cannula is implanted either bilaterally or unilaterally from within the cranium, serving the functions of drug administration or electrode placement. The inner injection tube is used for injecting drugs; different inner injection tubes can be matched with the base, making it suitable for the precise injection of multiple drugs at the same location or different depth positions. Meanwhile, to better improve experimental efficiency, the microinjection cannula is further divided into single cannula for microinjection and double cannula for microinjection.

Schematic Diagram of Single Cannula for Microinjection

The double cannula for microinjection enables the simultaneous injection of two different drugs at the same location

       The microinjection cannulas produced by Changsha Maiyue Biotechnology Co., Ltd. are specifically designed for intracranial drug administration in animals. They are used in conjunction with a stereotaxic instrument to pre-implant the cannula into a specific brain region, and long-term, multiple intracerebral administrations can be performed through the inner injection tube—even when the animal is in a conscious state. The microinjection cannulas can avoid repeated brain tissue damage caused by multiple punctures; through cannula implantation, multiple and repeated quantitative drug administrations can be achieved. Key parameters such as implantation depth can be customized to realize single-tube or double-tube microinjection.